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National Repository of Grey Literature

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Possible association of polymorphisms in COMT gene with mental diseases TOMANOVÁ, Aneta This thesis i focused on associacion of polymorphisms in COMT gene with mental diseases, primarily on polymorphism Val158Met. The theoretical part provides definitions of COMT gene and enzyme, catecholamines affected by COMT and definition of the polymorphism Val158Met. Next is listing of mental diseases, description and known connection with researched polymorphism. The practical part contains proceeding of PCR RFLP used to detect the genotype. The results were evaluated and connected to the theoretical part of the thesis. Detailed record

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